Actualité sur les infections transmises par le donneur en transplantation
JOURNÉE DU GTI 2024 > 1 février 2024
Membres du comité
Hannah Kaminski, Filomena Conti, Anne Scemla, Edouard Forcade, Jérôme Dumortier, Eric Epailly, David Lebeaux, Olivier Lortholary, Emmanuel Morelon, Cynthia Virone, Nassim Kamar, Florence Ader, Agnès Lefort des Ylouses, François Parquin
The HORUS project unites solid organ transplantation (SOT) experts, computational data scientists, virologists and immunologists in a fully operating European network consisting of 24 partners.
SOT is the optimal treatment for end-stage organ failure. However, the immunosuppressive drugs used to prevent graft rejection increase the risk of opportunistic infections. Among these infections, cytomegalovirus (CMV) leads to the most frequent morbidity, and can lead to mortality.
The ambitious but realistic goal of HORUS is to improve our understanding of CMV/host interactions in the context of immunosuppression, with a particular focus on:
- The characterisation of signatures associated with the control of CMV replication after transplantation
- The characterisation of signatures associated with evolution toward a difficult-to-treat CMV disease and poor outcome during CMV replication
- The discovery of new specific immunomodulatory molecules promoting CMV control while maintaining the prevention of acute rejection
Consultez les programmes et Meeting report 2023 ci-dessous.